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USE RESPONSIBLY
Ketamine is generally one of the safer drugs out there, as it does not present any respiratory depression even at the higher anaesthetic doses, is not found to be neurotoxic, and it is very hard to overdose on. Due to the way it acts in the brain it is also not associated with any comedowns and in some instances, it is even thought to reduce neurotoxicity induced by other substances, most popularly MDMA. By itself, the most well-known risks are ataxia aka lack of orientation, slurred speech, etc. which in high enough doses can lead to leaving users unconscious. To minimise the risks of injuring yourself, we recommend that you start with low amounts and redose your way up if you’re planning to venture into the infamous K-Hole.

DOSAGE
If you are planning on staying up and about on this drug, doses of 40 – 80mg insufflated are generally considered best. If youre looking to K-Hole, you would be looking at about 3mg per kg of body weight. E.g. someone who weighs 70kg should dose around 200mg. Note that it is best to build your way up to this dose through 5 lines of 40mg each as that will ease you into the hole, rather than taking it all at once which can leave you disoriented. Here is the dosage chart according to TripSit
Light: 20 – 50mg
Common: 50 – 125mg
Strong: 125 – 175mg
Heavy: 175mg or more